Human thyroxine-binding globulin and thyroxine-binding pre-albumin: dissociation rates
نویسندگان
چکیده
منابع مشابه
Thyroxine-Binding Globulin Concentrations
Plasma thyroid hormone concentrations may be abnormal in non-thyroid disease and pose diagnostic problems. For example, concentrations of triiodothyronine (T3) in the blood decline in acute illness with a reciprocal increase in reverse triiodothyronine (reverse T3), but thyroxine (T4) concentrations are usually normal or only slightly decreased (1, 2). However, McLarty et al. (3) reported that ...
متن کاملStudies on Human Thyroxine - Binding Globulin
to large volumes of serum may be due to adsorption of neuraminidases to the Sepharose either directly from serum or as the result of bacterial contamination. Partial desialylation of TBG in vivo may be an early step in the catabolism of this protein.
متن کاملFamilial thyroxine-binding globulin deficiency.
Genetically determined thyroxine-binding globulin deficiency is described in two families in the United Kingdom. All subjects in both pedigrees were euthyroid. Transmission was by sex-linkage; males showed low serum protein bound iodine and high thyroxine (T4) resin uptake due to complete absence of serum thryroxine-binding globulin; females were less severely affected. The distinctive biochemi...
متن کاملRelative rates of transcapillary movement of free thyroxine, protein-bound thyroxine, thyroxine-binding proteins, and albumin.
The rate of appearance of labeled thyroxine (T4) and albumin in lymph from various areas after simultaneous i.v. injection of the labeled substances in conscious ambulatory sheep has been used to estimate the relative rates of transcapillary movement of stable T4 and albumin. Labeled T4 appeared in hepatic lymph at the same rate as albumin. In intestinal and leg lymph, labeled T4 appeared eight...
متن کاملThyroxine Binding by Human Serum Albumin*
Thyroxine and triiodothyronine are transported in the blood as noncovalent complexes with certain serum proteins. This has been shown by many investigators and was the subject of an extensive recent review by Robbins and Rall (1). The binding proteins are an a-globulin (called thyroxine-binding globulin), a prealbumin, and serum albumin. The first appears to be the most significant binder of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1971
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1971.sp009589